One of the great challenges in biomedicine is to understand the origin of the disease to improve early detection and increase the cure rate and to do what experts call molecular preventive medicine, ie identify those individuals who have a molecular greater risk of developing certain diseases to prevent them.
Metabolism is one process that best define the general state of the organisms
It is known that aging of the organism, and therefore the cells and tissues that compose it, is the biggest risk factor to suffer most of the rich world’s diseases, including cancer.
Now, scientists at the National Cancer Research Centre (CNIO), led by its director, Maria Blasco, in collaboration with Jose M. Mato, director of the Center for Cooperative Research in Biosciences (CIC bioGUNE) have shown in mice that the metabolic profile of a body indicates the degree of cellular aging and overall health.
These findings, published online today in the journal Aging Cell, could be useful for molecular preventive medicine, and that would indicate the health of a quick and minimally invasive, and help prevent or diagnose disease stages is more initials.
In order to study a possible link between metabolism and aging, the authors have used a novel methodology, techniques based on liquid chromatography and nuclear magnetic resonance study has allowed in 130 mice to 1,500 metabolites, intermediates and products of metabolism, from very small sample of only 5-10μl of blood serum.
“Through this new technique we have seen that the metabolic profile of mice depends on their biological age. Specifically we found 48 metabolites that vary very significantly with age, “says Bruno Bernardes of Jesus, one of the authors of the study and researcher at the CNIO.
The benefits of aging slowly
When the researchers performed the same analysis in mice expressing telomerase Most those who age more slowly, according to a study recently released by the laboratory in the journal Blasco EMBO Molecular Medicine, observed that the metabolic label was very similar to younger mice.
When did these analyzes in telomerase-deficient mice who age faster-gauged a metabolic profile very similar to that of older animals. In fact, recent studies in humans suggest a possible link between metabolism and life expectancy.
“Our large-scale analysis, including a number of metabolites never analyzed so far, validate the theory that the metabolome sample accurately show the cell biological clock,” says Jose M. Mato.
New biomarkers for assessing health
Aging is characterized largely by metabolic decline results in a loss of hepatic, renal, or cardiac coronary well as increased risk of cancer. In fact, some of the 48 metabolites identified in the study have been previously associated with age-related diseases such as Alzheimer’s and cardiovascular diseases.
For authors, the results of this new research may be useful in predicting the overall health status in humans, by obtaining a small blood sample. It could also prevent related illnesses over the years, which are the most deadly diseases in rich countries.
In the future, researchers find also pose diagnostic biomarkers that are associated with diseases with a high socioeconomic impact, such as diabetes, obesity or cardiovascular disease.